Abstract

CORRELATION AMONG CYSTATIN C, OSTEOCALCIN, AND FIBRONECTIN SERUM AND SALIVARY LEVELS IN SUBJECTS WITH DIABETES AND\OR PERIODONTITIS COMPARED TO CONTROLS.

Amina Hamed Ahmed, Abdulsalam Tawfeeq Salih Alsamarai,Abdulghani Mohamed Alsamarai* and Wesam Suhail Najem

ABSTRACT

Background: Aim: To determine the correlation among salivary and serum levels of cystatin C, osteocalcin, and fibronectin in subjects with diabetes and periodontitis alone or in combination compared with control. Study Design: Prospective case control study. Materials and Methods: A total of 226 subjects recruited from Endocrinology Unit, Samara General Hospital during the period from 1st October 2014 to end of October 2015. Their age ranged from 32 to 75 years. The study population depending on their clinical and laboratory findings divided in to non- diabetic without periodontitis as control, diabetic, periodontitis without diabetes, and diabetic with periodontitis groups. Blood and salivary samples collected from subjects and serum isolated. Salivary and serum samples tested for cystatin C, osteocalcin and fibronectin using enzyme linked immunosorbant assay. Results: There was a significant correlation between serum and salivary cystatin, osteocalcin and fibronectin in control group, periodontitis group, diabetic group and periodontitis subjects with diabetes. In addition, in diabetic group, there was a significant correlation between serum osteocalcin and serum cystatin; serum osteocalcin and serum fibronectin; salivary osteocalcin and salivary fibronectin. While in those with diabetes and periodontitis, there was a significant correlation between serum osteocalcin and salivary cystatin; salivary osteocalcin and serum cystatin; salivary osteocalcin and salivary fibronectin. Conclusion: Patterns of significant correlation are the same in control and periodontitis groups, while it is different in diabetic group and Periodontitis with diabetes. Presence of periodontitis with diabetes alter the trend of association.

Keywords: Diabetes, periodontitis, cystatin, osteocalcin, fibronectin, saliva, serum.