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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

CARDIOPROTECTIVE POTENTIAL OF HYGROPHILA AURICULATA (L.) LEAVES METHANOLIC EXTRACT AND ITÃ¢â‚¬â„¢S SUB-FRACTION AGAINST DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS.

Vishnu Neharkar*, Dr. Girendra Gautam and Dr. Ramdas Pandhare

ABSTRACT

Myocardial infarction is the common presentation of the ischemic heart disease.Herbal medicines is getting more importance in the treatment of heart diseases because the modern synthetic medicines have limitation in their use due to side effects. Present study was designed to investigate the protective effect of Hygrophila auriculata L. (family: Acanthaceae) against cardiotoxicity induced by doxorubicin. Administration of doxorubicin (25 mg/kg i.p.) induced cardiomyopathy by significant elevation in serum creatine kinase (CK), lactate dehydrogenase (LDH), triglycerides, cholesterol & lipid peroxidation activities with a corresponding decrease in SOD, CAT, GSH level in tissue homogenate. Oral administration of methanolic extract of Hygrophila auriculata leaves (100, 200& 400mg/kg) & itâ€™s different fraction like petroleum ether fraction, n-butanol fraction, chloroform fraction & ethyl acetate fraction (100 & 200 mg/kg) prior to doxorubicin produced a significant cardioprotective activity. Methanolic extracts of Hygrophila auriculata leaves & its n-butanol fraction at dose 200 mg/kg shows reduction in mortality & restoration of altered cardiac marker enzymes. The histopathological studies also supported the protective properties of Hygrophila auriculata leaves, animals pre-treated with Hygrophila auriculata leaves extract showed a marked protective effect with decreased necrotic zones and revealed normal cardiac muscle bundles. Present study showed that Hygrophila auriculata leaves methanolic extract & its n-butanol fraction significantly restores most of the biochemical and histopathological parameters. These result indicates that Hygrophila auriculata leaves methanolic extract have significant cardioprotective activity.

Keywords: Cardioprotective, Doxorubicin, Hygrophila auriculata, Myocardial infarction.

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