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Abstract

EPIGENETIC MODIFICATION IN CANCER THERAPY: A REVIEW

Agilan N., Prakash A.* and Sambath Kumar R.

ABSTRACT

The mechanism of epigenetic are essential in the normal development and maintenance of gene expression patterns in mammals. Disruption of epigenetic processes results in malignant cellular transformation and altered gene function. Epigenetic aberrations has led to the emergence in the promising field of epigenetic therapy, with the recent FDA approval of epigenetic drugs for cancer treatment. The aim of this review work is to explain the current progression in the alterations of epigenetics in cancer and the changes in cancer initiation,progression and the potential use of this knowledge in designing most effective treatment methods.

Keywords: Epigenetics, DNA Methylation, Histone Modification, Chromatin Remodelling.


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