Abstract

EVALUATION OF ANTINOCICEPTIVE ACTIVITY OF OXALIS CORNICULATA IN STREPTOZOTOCIN INDUCED DIABETIC RATS.

Arijit Dutta*, Mangala Lahkar and Chimi Handique

ABSTRACT

Background: Oxalis Corniculata is traditionally well known for its versatile uses. The present study was carried out to evaluate the antinociceptive action of ethanolic extract of Oxalis corniculata in Streptozotocin induced diabetic albino rats. Method: To look for the antinociceptive effect the albino rats were divided into 5 groups, each consisting of 6 animals. Diabetes was induced by a single i.p. injection of Streptozotocin at a dose of 50mg/kg body weight. Standard drug, Pentazocine was fed to one group in the hot plate model and Aspirin was fed as the standard drug in acetic acid induced writhing model. Ethanolic extract of Oxalis corniculata (EEOC) at doses 200mg/kg and 400mg/kg body weight was fed to the rats in the test groups. Results: The antinociceptive property of the extract has shown increasing trend with increase in dose of the extract. Conclusion: Results obtained in this study substantiate the anti-nociceptive activity of EEOC leaves in streptozotocin induced diabetic rats.

Keywords: Antinociceptive; Oxalis Corniculata ; Streptozotocin.