Abstract

ANALGESIC ACTIVITY OF METHANOL EXTRACT OF CORIANDRUM SATIVUM LINN FRUIT

M. Padmaa Paarakh*, Jai Kumar S. and Rupesh M.

ABSTRACT

The analgesic activity of 75 % methanol extract fruit of Coriandrum sativum Linn were tested against Eddy’s hot plate method and tail flick method. Animals were treated with distilled water, paracetamol and 100, 200,400 mg/kg body weight 75 % methanol extract of C.sativum. In hot plate method, the reaction time (in seconds) or latency period was determined as the time taken for the rats to react to the thermal pain by either Paw licking or jumping. The reaction time was recorded before (0 min) and at 30, 60, 90, 120 and 150 min after the administration of the treatments. In tail flick method, the response time was noted as the sudden withdrawal of the tail from the hot water. The reaction time was recorded before (0 min) and at 30, 60, 90, 120 and 150 min after the administration of the treatments. The result in the hot plate study shows that 100 mg/kg is very effective when compared to 200 and 400 mg/kg extract and in tail flick method 400 mg/kg had better effect when compared to 100 and 200 mg/kg extract. The above results suggest the analgesic activity of the 75 % methanol extract of fruit of C.sativum.

Keywords: Coriandrum sativum, analgesic activity, Eddy’s hot plate method, tail flick method, paracetamol