Abstract

PROTECTIVE ROLE OF ALOE VERA AGAINST ALUMINIUM INDUCED CHANGES IN LIVER ENZYMES ACTIVITY (ALT, AST AND ALP) OF ALBINO RATS, RATTUS NORVEGICUS

Laxman K. Jakkala*, Sharique A. Ali Ram Kumar Choudary and Gajendra Mahor

ABSTRACT

The present study was carried out to investigate the protective role of Aloe vera plant extract on aluminium induced changes in liver enzymes of albino rats. Aloe vera is a medicinal plant belonging to the family –Liliaceae, which has a wide range of therapeutic applications such as wound healing, diabetes, burns, for easing intestinal, curing ulcers and arthritic swellings. 30 adult rats were taken and divided into 3 groups 10 (5+5) for each. Animals were fed with normal diet and water adlibitum, as Group I or control group. Group II animals were fed with normal diet and received aluminium sulphate in a dose of 98 mg/kg of body weight orally for 30 and 60 days. Group III were fed with normal diet and received aloin (100mg/kg body weight) and aluminium sulphate (98 mg/kg body weight) for 30 and 60 days. On the last day of the experiment animals were sacrificed by cervical dislocation on 30th and 60th days respectively. Liver was removed and homogenized in buffer, homogenate was centrifuged and supernatant was used for further analysis. The results of the present study clearly indicated that aluminium sulphate has significantly elevated the normal levels of liver enzymes such as Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP). But after co-treatment of rats with aloin the extract of Aloe vera and aluminum sulphate, the levels of above mentioned liver enzymes reached near to normal level, indicating the protective role of aloin against aluminium sulphate toxicity.

Keywords: Aluminium Toxicity, Aloe vera, Albino Rats, estimation of rat liver enzymes, Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP).