Abstract

“CORRELATION OF SERUM, SALIVARY IgA WITH SERUM, SALIVARY TOTAL PROTEINS IN ORAL SUBMUCOUS FIBROSIS PATIENTS”- A STUDY

Dr. S. Priyanka,* Dr. K. SaraswathiGopal and Dr. A. Vignesswary

ABSTRACT

Background: Oral submucous fibrosis (OSMF) is a potentially malignant condition in which its etiopathogenesis is multifactorial and still obsure. Immunological process is one of the responsible and its hyperimmunoglobulinaemia is concurrently associated with OSMF. Total proteins can be used as biochemical indicators for nutritional assessment. Aim: The aim of the present study is to correlate the levels of serum, salivary IgA with serum, salivary total proteins among OSMF patients. Materials and methods: Serum, salivary IgA and its total proteins quantitative estimations are carried out by turbidometric immunoassay through spectrophotometer in 30 OSMF patients and equal age and sex matched healthy controls. The obtained data are analyzed using pearson chi-square and independent samples T- tests. Results: The results indicated significant elevated levels of serum, salivary IgA and significant decrease of serum, salivary total proteins concurrent to the increase of grades in the OSMF when compared with controls. Conclusion: Immunology has a role in OSMF and there is imbalance of immunoregulation as well as alteration of local tissue architecture.

Keywords: IgA, oralsubmucous fibrosis (OSMF), Total proteins.