Abstract

NANOPARTICLES AS – PARTICULATE DRUG DELIVERY SYSTEM

Sarika Anand Jadhav*, Prof. Prashant Patil and Dr. Ramesh Kalkotwar

ABSTRACT

Nanoparticles are particulate dispersions or solid particles with a size in the range of 10-1000nm. Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate and dose regimen.In this review the most important preparation methods are described, The most important methods of nanoparticle preparation, as well as the encapsulants and the Resulting approximate particle sizes especially those that make use of natural polymers. Nanoparticle shows their controlled- and sustained-release properties, subcellular size, and biocompatibility with tissue and cells. Nano particulate systems with hydrophilic polymers is the most common way to control the opsonisation process and to improve the surface properties of the system, or coating modification with polymers such as the attachment of poly(ethylene glycol) (PEG) chains to biodegradable polymer such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA). This articles represents the method of preparation of nanoparticles, with there advantages disadvantages and evaluation parameter of nanoparticles.

Keywords: Nanoparticles, biodegradable, polymers, method of preparation.