Abstract

ORAL PROSOPISJULIFLORA TREATMENT AMELIORATES INFLAMMATORY RESPONSES AGAINST CARRAGEENAN INDUCED PAW EDEMA IN RATS

P.K.Choudhary*, B.P. Nagori

ABSTRACT

Prosopisjuliflora (Leguminosaceae) is a shrub which is traditionally used to treat, colds, diarrhea, dysentery, inflammation, itching, measles, sore throat, and wounds. The plant also possesses antiemetic, antibacterial, expectorant and antisepticactivities. In lieu of the same, the present study was designed tophytochemically screen and evaluate the anti-inflammatory potency of the ethanolicextract of leaves of Prosopisjuliflora(100, 200, and 400 mg/kg)againstcarrageenan induced paw edema in rats. The preliminary phytochemical screening revealed the presence of flavonoids, saponins, carbohydrates, cardiac glycosides, tannins, and alkaloids in ethanolic extract of the leaves of Prosopisjuliflora. The oral median lethal dose was found to be 3807.9 mg/kg in mice and > 5000 mg/kg in rats.Our result depicted that the extract significantly attenuated the pawedema with the highest activity observed at dose of 400 mg/kg. This study supports the folkloric claim of the use of Prosopisjuliflorain the management of inflammations.

Keywords: Prosopisjuliflora,Rat pawoedema , carrageenan, Anti-inflammatory.