Abstract

VITAMIN D AND GLYCATED HEMOGLOBIN (HbA1c) LEVELS IN TYPE 2 DIABETES MELLITUS

*Vijay Chaudhary, Dr. Neeru Bhaskar, Dr. P. D. Gupta, Anit Lamichhane, Dr. Suvarna Prasad and Dr. K. S. Sodhi

ABSTRACT

Introduction: Diabetes, metabolic disease, is increasingly common and characterized by inappropriate increases in blood glucose concentration due to inadequate insulin action in the body. About 170 million people are affected worldwide. About 90% of diabetic patients around the world have type 2 diabetes mellitus (T2DM) according to the World Health Organization. About 10% of the Indian population suffers from this disease. Vitamin D deficiency and diabetes mellitus are two common conditions. Vitamin D levels having been found to be inversely related to glycosylated hemoglobin levels in diabetes mellitus. Materials and Methods: 100 diagnosed patients were taken. Poorly controlled T2DM patients were selected randomly of either sex from age group 35 to 70 years. 50 age and sex matched apparently healthy subjects having normal glycated hemoglobin, were taken. The study protocol was approved by Institutional Research Committee. Biochemical measurements were determined by standard procedures and the result was presented in mean ± standard deviation. Results: HbA1C levels were higher in the diabetes mellitus type 2 patients than in the control group. HbA1 levels are 8.1±1.09 % and 5.54±0.30 % in the patient and control groups, respectively. The diabetes patients had serum vitamin D levels 19.09 ± 5.34 and the control group had vitamin D levels 26.7 ± 3.46 ng/ml. Conclusion: High HbA1C concentrations are associated with a low concentration of serum vitamin D in type 2 diabetic patients independently of the duration of diabetes, diabetes treatment and nephropathy.

Keywords: Type 2 Diabetes Mellitus, Vitamin D, Glycated hemoglobin, Insulin.