Abstract

ANTIHYPERGLYCEMIC AND ANTINOCICEPTIVE ACTIVITY OF LANNEA COROMANDELICA (HOUTT.) MERR. BARK INVIVO.

Sk Abrar Shahriyar, Nasrin Sultana, Mahmadul Haque, S M Shamsul Islam*

ABSTRACT

Lennea coromandelica is a plant commonly used in the traditional medicine to treat inflammation,pain, wounds, and boils. The aim of this study was to evaluate the antihyperglycemic and antinociceptive activity of ethanol extract of leaves of L. coromandelica (EELC). EELC was investigated using various nociceptive models induced thermally or chemically in mice including hot plate and tail immersion test, acetic acid-induced writhing, oral glucose tolerance test (OGTT) and formalin-induced licking tests at the doses of 50, 100, and 200 mg/kg body weight (p.o.). In addition, to assess the possible mechanisms, involvement of opioid system was verified using Alloxan (120 mg/kg) and methylene blue (MB; 20 mg/kg). The results have demonstrated that EELC produced a significant and dose-dependent increment in the hot plate latency and tail withdrawal time. It also reduced the number of abdominal constrictions and paw lickings induced by acetic acid respectively. EELC inhibited the nociceptive responses in both phases of formalin test. Besides, the reversal effects of alloxan indicated the association of opioid receptors on the exertion of EELC action centrally. A standard antinociceptive drug, diclofenac sodium, when administered at a dose of 400 mg per kg body weight reduced the number of writhings by 60.5%. The results suggest that the plant may be used for further scientific studies leading to isolation of active phytochemical constituents, which can prove useful as novel and more efficacious pain- killing drugs.

Keywords: Lennea coromandelica, antihyperglycemic, antinociceptive.