Abstract

EVALUATION OF THE HEPATOPROTECTIVE ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS FROM GOMPHRENA CELESIOIDES, COLA NITIDA AND ENTENDROPHRAGMA ANGOLENSE AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS.

Bamba Abou*, Yapi Houphouet F., Gogahy Konan, Djyh Bernard N., Oungbé Monkoué D. and Zougrou N’guessan E.

ABSTRACT

Entandrophragma angolense, Cola nitida and Gomphrena celosioides are plants used by traditional Ivorian medicine for the treatment of several diseases including liver disease. The aqueous and ethanol extracts of these plants were the subject of several studies around the world, however, there is still much to do as for the elucidation of their hepatoprotective properties. The point of this study was to evaluate the hepatoprotective properties of extracts of these three plants. The extractions were carried out by maceration. Hundred (100) g dry powder of plant in 2 liters of distilled water (aqueous extraction) or in 2 liters of water/ethanol mixture (30/70 V/V) (ethanol extraction). As regards the hepatoprotective properties, Rats were pretreated with the extract (200 and 500 mg/kg) by silymarin (100mg / kg) for a week. Then, liver toxicity was induced by carbon tetrachloride 20% (5ml/kg) on the seventh day. The results showed that the extracts studied, lower the effect of CCl4 on biochemical parameters, reducing (P˂0.05) serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), the alkaline phosphatase (ALP), gamma-glutamyl transferase (γ-GT) and total bilirubin. This study reveals that the studied extracts possess more interesting hepatoprotective properties for ethanol extracts at 500mg / kg. The ethanolic extracts of C.nitida, and E.angolense at 500 mg /kg give results comparable to that of silymarin.

Keywords: Gomphrena, Entandrophragma, Cola, hepatotoxicity, silymarin, CCl4.