Abstract

CYTOTOXICITY OF TiO2 AND ZnO AS UV FILTERS FOR PREVENTION SKIN CANCER

Mauricio Alexandre Reis Junior*, Juliana de Santana Reis, Marcos Antônio Corrêa, Jonata Augusto de Oliveira, Vera Lucia Borges Isaac

ABSTRACT

The constant and excessive exposure to solar radiation can result in the onset of various injurious effects, such as: formation of reactive oxygen species, mutation in DNA and RNA, inflammation and epidermal hyperplasia. According to the data provided by Skin Cancer Foundation, the number of nonmelanoma skin cancers in the US increased by nearly 77 percent between 1992 and 2006. The use of UV filters is one of the most efficient actions of prevention skin cancer. However, most of the UV filters are unstable to the UV irradiation and permeation into the skin. The objective this review is extends our knowledge about the mechanisms of action and cytotoxicity of inorganic UV filters for prevention skin cancer.

Keywords: skin cancer; cytotoxicity; UV filters; mutation.