Abstract

SYNTHESIS AND EVALUATION OF NEW ORGANIC UV FILTERS FOR PREVENTION SKIN CANCER

Mauricio Alexandre Reis Junior*, Juliana de Santana Reis, Jonata Augusto de Oliveira, Marcos Antônio Corrêa and Vera Lucia Borges Isaac

ABSTRACT

The constant and excessive exposure to solar radiation can result in the onset of various injurious effects, such as: formation of reactive oxygen species, inflammation, epidermal hyperplasia, reduction collagen synthesis, photoaging and mutation in DNA and RNA. According to the data provided by National Cancer Institute (INCA), the number of cases of skin cancer increases gradually as a result of the destruction of the ozone layer. The use of photoprotective formulations is one of the most efficient actions of prevention skin cancer. However, most of the photoprotective emulsions are unstable to the heat and UV irradiation. The aim of developing new organic UV filters is increase the efficacy and to reduce photodegradation and permeation into the skin. The innovative strategy used for to increase the efficacy of sunscreens is the addition of compounds with antioxidant properties and PMMA-encapsulated of UV filters. The objective this review is extends our knowledge about the mechanisms of action of new organic UV filters for prevention skin cancer.

Keywords: skin cancer, photoprotection, UV filters, photodegradation.