Abstract

SYNTHESIS AND EVALUATION OF SCHIFF BASES OF 5- SULFAMOYL ISATIN FOR THEIR ANTIMICROBIAL AND ANTI- INFLAMMATORY ACTIVITY

Srikanth Lingala*, Naveenchandra Kotagiri, Raghunandan Nerella.

ABSTRACT

In view of various biological activities and enormous importance of indoles, isatins and their derivatives, it was our interest to synthesize and characterize some new Schiff bases of 5 - Sulfamoyl Isatin and evaluate them for antimicrobial and anti-inflammatory activity. An appropriate quantity of 5-Sulfamoyl-1H-Indole-2,3-dione was stirred well and refluxed with hydrazinhydrate in alcohol to give 5-Sulfamoyl isatin hydrazone which was then heated under reflux with various aromatic aldehydes to give new Schiff bases of 5 - Sulfamoyl Isatin derivatives. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the synthesized compounds were screened for antibacterial activity against B. subtilis, B.cereus, S. epidermidis, S. typhi, P. aeruginosa and K. pneumoniae, antifungal activity against A.flavus, F.oxysporium and P. notatum and anti-inflammatory activity using carrageenan induced rat paw edema model. Most of the compounds tested have shown promising activities when compared with the standard drugs.

Keywords: Isatins, Antimicrobial activity, Anti inflammatory activity, Amikacin,