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DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHY METHOD FOR THE ANALYSIS OF ALFUZOSINE HCL IN PHARMACEUTICAL DOSAGE FORMS
*Vilas Arsul, Manoj Shere and Supriya Wagh
ABSTRACT The objective of the current study was to develop a simple accurate, precise and rapid RP-HPLC method development and validation for determination of Alfuzosine HCl in tablet dosage form. Chromatographic separation was achieved on C18 Column with mobile phase Acetonitrile :( 0.05%) OPA (40:60) v/v with flow rate 0.7ml/min and UV detection was carried out on 245nm. Retention time of Alfuzosine HCL was found to be 4.9167 & Linearity of proposed method was found to be in the range of 10-50 μg/ml (r2=0.997). Method was statistically validated for its linearity, accuracy and precision. Both interday and intraday variation was found to be showing less %RSD (Relative Standard Deviation) value indicating high grade of precision of method. Keywords: RP-HPLC Method, Alfuzosine HCl, Validation. [Download Article] [Download Certifiate] |