METHOD DEVELOPMENT AND VALIDATION OF VORICONAZOLE INJECTION BY RP-UPLC
Pavani.P, Palanichamy.S, Ramasubramaniyan.P*, Srinag.T , Lakshmi M Solairaj.P
ABSTRACT
We developed a simple, rapid, sensitive, accurate analytical method for
determination of voriconazole injection by RP-UPLC method.
Chromatography was performed with mobile phase containing sodium
dihydrogen orthophosphate and acetonitrile, with a flow rate of
1.0ml/min,C-18 column and PDA-detection at 254nm and run time of
5 mins. Validatiom parameters system precision, accuracy, linearity,
robustness as per ICH guidelines.
Keywords: RP-UPLC, voriconazole, ICH guidelines.
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