Abstract

ROLE OF BACTERIAL PROTEINS AZURIN AND RUSTICYANIN ON TUMOR SUPPRESSOR PROTEIN P53 FOR TREATMENT OF CANCER

*Divya K. Damania

ABSTRACT

Apoptosis is a cellular death programs to maintain multicellular organisms by discarding damage and undesirable cells. Faulty execution of apoptosis makes cells mortal or immortal. Cancer result due to immortalization of cells. Cell growth is control by dual functioning of cdks and tumour suppressor protein. Majority of cancers is result of p53 tumour suppressor protein thus efforts are made to improve p53 function. Bacterial redox protein such Azurin and Rusticyanin known to form complex with p53 protein, stabilize and increase its intracellular level and produce apoptosis. These bacterial redox proteins can be used as vehicle to transport therapeutics to cancer cells. Azurin protein transduction domain specifically penetrates cancer cells and produce cytostatic and cytotoxic effects. Similarly Rusticyanin also produce cytotoxicity but non-specific towards cancer and normal cells.

Keywords: Azurin and Rusticyanin.