Abstract

HEPATOPROTECTIVE ACTIVITY OF NATURAL AND SYNTHETIC POORA PARPAM AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN WISTAR RATS

N. Kabilan* and M. Murugesan

ABSTRACT

Liver being a vital organ of human body controls the most important biologically significant process called metabolism. Cytochrome group of enzymes in liver constantly involved in detoxifying the drugs, chemicals and their corresponding metabolites were been excreted with the help of kidney. Certain toxicants on long-term exposure have potential of damaging hepatocytes which in turn affects the metabolic function of the liver. Siddha system of medicine is considered to be one of the oldest rejuvenating therapies known to mankind since centuries back. Siddha formulations have consistently proven its efficacy particularly in the management of liver disease. In the present study, liver rejuvenating effect of siddha formulations natural and synthetic Poora parpam was evaluated against carbon tetrachloride induced hepatotoxicity in wistar rats. Animals are divided in seven groups of six animals each. Liver damage was induced in all groups except control group, with 1:1(v/v) mixture of CCl4 and olive oil (1ml/kg, s.c.) while, olive oil (0.5 ml/kg, s.c.) was injected to control group. The liver damage was evidenced by elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total bilirubin, direct and indirect bilirubin. The results obtained from the study reveals that treatment with natural and synthetic Poora parpam at both the dose levels (1.15 and 2.30mg/kg) significantly reduces the level of liver enzymes such as SGOT, SGPT and ALP further it was observed that there was significant decrease in the level of serum bilirubin level when compare to that of the standard drug silymarins, further these findings were supported and confirmed by histological examination.

Keywords: Hepatoprotective, Natural Poora parpam, Synthetic Poora parpam, CCl4, SGOT, SGPT, ALP, serum bilirubin.