Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ANNONA SQUAMOSA LEAVES AND BARK EXTRACT AGAINST CARBON TETRACHLORIDE LIVER DAMAGE IN WISTAR RATS.

Neha Sonkar, Anil K. Yadav*, Pushpesh K. Mishra, P. K. Jain, Chandana V. Rao

ABSTRACT

The ethanolic extract of the leaves and bark of Annona squsmosa. (Annonaceae) was evaluated for hepatoprotective activity in wistar rats with liver damage induced by carbon tetrachloride. The extract at an oral dose of 450 mg/kg exhibited a significant protective effect by lowering the serum levels of aspartate aminotransferase, alanine aminotransferase, total serum bilirubin, and malondialdehyde equivalent, an index of lipid peroxidation of the liver. These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of silymarin, a known hepatoprotective.

Keywords: Annona squsmosa, Leaves and bark, Hepatoprotective; Carbon tetrachloride.