Abstract

IMPROVING THE SOLUBILITY OF ESOMEPRAZOLE USING SELF NANOEMULSIFYING DRUG DELIVERY SYSTEMS

Sangeet Sharma and Dinesh Kauhsik*

ABSTRACT

An ideal drug delivery system possessing the two main properties that are with single dose or less frequent and the dosage form with ability to release active drug directly at the site of action are widely accepted by patients. Esomeprazole, a proton pump inhibitor (antiulcer agent) is a poorly water soluble drug with a pKa value 4.2 having a pH dependent solubility and dissolution rate. In the self emulsification study it was found that there was no phase separation (turbid) solution all the dilutions were clear and transparent liquid which indicate that micro emulsion will formed easily in stomach (0.1N HCl) and intestine (phosphate buffer 6.8 pH) under mild agitation means faster dissolution and hence absorption.

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