Abstract

EVALUATION OF ANTICONVULSANT ACTIVITY OF LEAF OF DRYPETUS ROXBURGII

Akshara*, Akshay Kumar K., Kuppast I. J., Narayan Murthy G., Vijaykumar M. L. and Prabha Hullatti

ABSTRACT

Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupt the nervous system and can cause mental and physical dysfunction. The ethanol and aqueous extract of the leaf of plant Drypetes roxburgii was evaluated for its antiepileptic activity in Swiss Albino Mice at 500 mg/kg body weight. Antiepileptic activity was assessed by using Maximal Electroshock induced Seizures [MES] method. Both extracts showed reduction in the duration of all the phases of epilepsy such as Flexion, extensor, convulsion, stupor phases. The results are promising for further investigation for efficient anticonvulsantactivity.

Keywords: Epilepsy, Flexion, extensor, convulsion, stupor phases, Maximal Electroshock induced Seizures.