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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEWER 1,2,4-TRIAZOLO [3,4-b][1,3,4] THIADIAZOLE DERIVATIVES
Jagdish K. Sahu*, Neha Sahu and Atul Kaushik
ABSTRACT
A series of 6-alkyl-3-(3,4 –dialkoxyphenyl) -[1,2,4]triazolo [3,4- b][1,3,4] thiadiazole (7a-7h) were synthesized by condensing 4-amino-5-(3,4-dialkoxyphenyl)-4H-[1,2,4]- triazole-3-thiol (6) with various acyl chlorides through one-pot reaction. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the synthesized compounds were screened for their antimicrobial activity against a variety of microorganisms. Keywords: Synthesis, Triazolothiadiazoles, Antibacterial activity, Antifungal activity. [Download Article] [Download Certifiate] |