Abstract

ANTICANCER EFFICACY OF ROOT TISSUE AND ROOT-CALLUS OF ACANTHUS ILICIFOLIUS L., ON BENZO (A) PYRENE INDUCED PULMONARY CARCINOMA IN MUSMUSCULUS

*Chinnappan Ravinder Singh and KandasamyKathiresan

ABSTRACT

Acanthus ilicifoliusL. (Holly Mangroves) an important mangrove plant species wasstudied for anti-pulmonary carcinoma. The callus was raised from the root explants with the help of different growth regulators. Maximum callus biomass was observed in 3mg/L of 2,4-D. Shade dried root materials and in vitrocultured root callus were extracted with 9:1 ratio of chloroform and methanol. Then the partially purified compounds were subjectedto in vivoanti-pulmonary carcinoma. Pulmonary carcinoma was induced by benzo(a)pyrene. After 16 weeks of treatmentthe animals treated with root callus extract were completely recovered from lung cancer. The significant resultswere observed fromboth lung and liver tissues.The animals treated with root callus extract showed better result than the field grown root extract. The plant Acanthus ilicifoliusdid not show any toxic effect.In this present study,Acanthus ilicifolius was found to be a natural preventive source of pulmonary carcinoma.

Keywords: Pulmonary Carcinoma,Anti-cancer drug, Plant growth regulators and Antioxidantsoxidants.