Abstract

PURIFICATION CHARACTERIZATION AND EVALUATION OF BUTEA MONOSPERMA GUM AS A RELEASE MODIFIER IN SOLID ORAL DOSAGE FORM

Darekar A. B.*, Desale K. B., Gondkar S.B. and Saudagar R.B.

ABSTRACT

The present study revealed Butea monosperma gum (BMG) as a pharmaceutical excipient, especially for oral drug delivery. Glipizide, used as model drug as a successful chemical entity as a anti-diabetic drug and numerous literature available for the same. A Glipizide was found to be suitable for the formulation and its oral solid dosage form with BMG. A sustained effect of Glipizide required for the treatment of Hypoglycemia. Plasma elimination half-life was 2 to 4 hrs. and hence, there was need to reduce the dosing frequency which can be done with use of sustained release dosage form. In the present investigation authors used novel polymer BMG with Sodium CMC for sustaining the action of drug up to 12hrs. Tablets were prepared using direct compression method and the dissolution study was done in acidic buffer (pH 1.2) for first 2 hrs. and in phosphate buffer (pH 6.8) up to 12 hrs. The physicochemical properties of tablets were found within the limits. The experimental value % drug release after 12hrs of optimized formulation was found to be 91.58%. From the work demonstrated it was concluded that the BMG can be used for its prolong sustained release effect and the optimized batch shown that the produced design was successful with Glipizide as a model drug.

Keywords: Butea monosperma gum, Sodium CMC, Sustained Release, oral solid dosage, hypoglycemia.