Abstract

CASE REPORT ON AMLODIPINE INDUCED PITTING PEDAL EDEMA

Merin Joseph*, Ammu A., Jasmin Elizabeth Thomas, S. Hemalatha, T. Sivakumar

ABSTRACT

Amlodipine is a third generation calcium channel blocker used in adults and children above 6 years old for the treatment of hypertension, angina and other coronary artery disease. Calcium channel blocker act by inhibiting the inward movement of calcium by binding to L-TYPE calcium channels in the heart and in smooth muscle of coronary and peripheral vasculature which leads to smooth muscle dilation and relaxation. The drug exhibits constant pharmacokinetics and pharmacodynamics and well tolerated. Amlodipine has more incidence of pedal edema than the other calcium channel blockers. Here we present a case of 66year old female patient diagnosed with hypertension, type II diabetes mellitus and gastritis who gradually develops pitting type pedal edema after the initiation of oral amlodipine 2.5mg for the treatment of hypertension. The symptoms improved on cessation of amlodipine and the patient was managed with an alternative antihypertensive agent.

Keywords: Calcium channel blocker, Amlodipine, Pitting pedal edema.