Abstract

FORMULATION AND EVALUATION OF SIMVASTATIN IMMEDIATE RELEASE TABLETS BY USING LIQUISOLID TECHNIQUE

A. Swathi Annapurna*, P. N. Mallikarjun, P. V. Kamala Kumari, S. V. V. Sravya

ABSTRACT

At present in pharmaceutical industry 40% of drugs in development pipelines and approximately 60% of drugs coming directly from synthesis are poorly soluble. The main objective of this study is to improve the dissolution and thereby availability of simvastatin a practically insoluble antihypertensive drug by liquisolid compact technique. Liquisolid compacts are prepared using PEG 200 as non volatile solvent, MCC as carrier and Aerosil as coating material. Simvastain was formulated as liquisolid compacts in different concentrations (5% and 10%) of drug in non volatile solvent (PEG 200) with different excipient ratio (R) (10, 15 and 20) were studied and the drug release behavior was compared with that of marketed product. The prepared liquisolid powders were mixed with a superdisintegrant (Sodium starch glycolate) and compressed in to tablets (F1-F6) and were evaluated for various post compression parameters such as hardness, friability, disintegration time and dissolution test. The formulated liquisolid compacts exhibited acceptable flowability, compressibility and given improved percentage of drug release (99.25%). Among all formulated tablets (F1-F6) simvastatin F6 formulation exhibited enhanced dissolution rate due to the wettability, producing of the super saturated microenvironment around the tablets. From this study it was concluded that liquisolid technique is an effective approach to enhance the dissolution rate of simvastatin.

Keywords: Simvastatin Liquisolid compacts, carrier material, coating material.