Abstract

REVIEW: IN SITU INTRANASAL GEL POLYMERIC DRUG DELIVERY

Sindhu Jaiswara*, G. R. Dixit, Dr. K. P. Upadhye and S. S. Bakhle

ABSTRACT

Gel is the state between the liquid and solid which consists of physically cross linked networks of long polymer molecules with liquid molecules trapped within a three dimensional polymeric network swollen by a solvent. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation from which the drug gets released in a sustained and controlled manner. Many natural, biodegradable, biocompatible and synthetic polymers like alginic acid, pluronic F127, xyloglucan, gellan gum, carbopol, pectin, chitosan, and poly-caprolactone etc. are used in the preparation of in situ gelling system. Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. In situ gelling system becomes very popular nowadays because of their several advantages over conventional drug delivery systems like sustained and prolonged release of drug, reduced frequency of administration, improved patient compliance and comfort.[2,4,5]

Keywords: alginic acid, pluronic F127, xyloglucan, gellan gum, carbopol, pectin, chitosan, and poly-caprolactone etc.