Abstract

COMPARISON OF PREVENTIVE EFFECT OF LOW DOSE KETAMINE AND ONDANSETRON IN THE PREVENTION OF SHIVERING AFTER SPINAL ANESTHESIA IN PATIENTS UNDERGOING ELECTIVE CESAREAN SECTION

Ahmad Reza Mohtadi, Seyed Mohammad Reza Goushe, Ali Ghomeishi, Nazli Arbabi*

ABSTRACT

Introduction: Post anesthesia shivering causes increased body's need for oxygen up to 500%, increased post operative pain, prolonged recovery, increased nausea - vomiting, high blood pressure, increased pressure in the eyes and brain. The aim of this study was to compare the effects of ketamine and ondansetron on preventing shivering after cesarean section. Method: This clinical trial study was conducted on 117 pregnant women referred to the women operating room of Imam Khomeini Hospital of Ahwaz during 2015-2016. The patients were randomly divided into three, 39-patient groups of ketamine and ondansetron and normal Saline. The first group received 0.25 mg/kg of ketamine and the second and third groups received 4 mg of ondansetron and only 10cc of normal saline, respectively. While entering the recovery room to 20 minutes later, shivering, blood pressure, nausea and vomiting, sedation and hallucinations were evaluated. Data analysis was performed using Repeated Measures ANOVA through the software SPSS20. Finding: Post- anesthesia shivering was observed in the ketamine group (5.1%), ondansetron group (17.9%) and in saline group (71.8%). The difference between ketamine and ondansetron groups and saline group was completely significant (p: 0.001). Although ketamine group patients were shivering less, but significant difference was not observed between ketamine and ondansetron groups in terms of shivering (p: 0.073). There was significant difference (p0.05). Conclusion: Patients receiving ketamine shivered to a lesser extent than ondansetron recipients, but this difference was not significant.

Keywords: ondansetron, ketamine, post anesthesia shivering, spinal anesthesia, elective cesarean section.