Abstract

STUDY OF DRUG USE EVALUATION ON ORAL ANTIHYPERGLYCEMIC AGENTS IN TYPE 2 DIABETES MELLIITUS AND THEIR POTENTIAL DRUG-DRUG INTERACTIONS

Angel Dominic*, Jijina Joseph, Rani Mariya Augustin, Rihanna Begum, Basavaraj K. Nanjwade

ABSTRACT

DUE is a system of ongoing, systematic, quality improvement process, which’s designed to review the drug use, & to develop criteria & standards which describe optimal drug use. Hypoglycemia is the common adverse drug reaction of antidiabetic drugs seen in some patients. In this regard drug utilization study was conducted to determine the rational use by describing the drug use pattern. The objective of the study was to evaluate the prescription pattern, assessment of drug interaction, also to evaluate the occurrence of diabetes type-2 with other comorbidities & also to assess the cost minimization. The studies were simple prospective observational study which was carried out for a period of six months in the oxford medical college and research centre, Attibele. 150 patients who satisfy the inclusion and exclusion criteria were included in the study. The information included patient demographic details like age, sex, body mass index, family history, comorbid conditions, number and class of medicines prescribed. Majority 43% of the patients were in the age group 40-60 years. It is seen that 56% were males & 44% were females. Monotherapy was prescribed more frequently during the hospital stay (70.66%). The results of overall usage of different OADD’s revealed that Metformin (40 %) was the most preferred drug of choice for type 2 DM. Comorbid condition was found in 114 patients. The study has shown that the major interaction occurs with anti diabetic and antibiotics which lead to arrhythmia and alteration of blood glucose levels. The present study concluded that biguanides was the most commonly prescribed class of oral hypoglycaemic drug in the oxford medical college & research center. It is seen that cost of glimepride is found to be more cost compared to metformin, but metformin cause serious major adverse effect lactic acidosis. So it should be given in combination. But at the same time if we use the combination drug the cost will be increased. So it’s better to use glimipride alone. Glimipride can be administered as once daily preparation, effect at low dose, additional anti-platelet activity, minimal adverse effects on cardiovascular system and lower incidence of hypoglyceimia.

Keywords: DUE, hypoglycemia, OADDS, metformin, glimipride, biguanides.