Abstract

RECENT ADVANCES IN THE SYNTHESIS OF ISOQUINOLINE AND ITS ANALOGUE: A REVIEW

Jemi Jacob*, Neethu Varghese, Shebina Rasheed, Supriya Agnihotri, Vidushi Sharma3 and Sharad Wakode

ABSTRACT

Isoquinoline or benzopyridine, 2-benzanine is a weak tertiary base. Isoquinoline ring has been found to possess wide range of biological and pharmacological activities like antimalarial, anti-HIV, insect growth retarding antitumor, antimicrobial, antileukmic antibacterial, Parkinson's disease activity and is a scaffold for chiral ligands. Isoquinoline is a important source of leads for drug discovery. To explore this chemical space several established protocols for the synthesis of Isoquinoline ring such as the Bischler-Napieralski Pictet-Spengler and Pomeranz-Fritsch reactions which all centre on the electrophilic aromatic substitution so are limited to electron-rich carbocycles. A number of new synthetic methodologies and modification of traditional procedure, which do not require highly-specialized starting materials are developed and reported time to time. Recent synthetic efforts have greatly expanded the diversity of isoquinoline motifs available. The article aims at highlighting these very recent advancements in the synthesis of the isoquinoline ring by the use of different starting material and catalyst.

Keywords: Isoquinoline, Synthesis, Cycloaddition.