Abstract

IN SITU GEL: APPLICATION AND USES OF POLYMERS

Snehal Nikode*, Gauri Dixit and Kanchan Upadhya

ABSTRACT

The development of in situ gel system has received considerable attention over the past few years. This interest has been sparked by advantages shown by in situ forming delivery system such as ease of administration and reduced frequency of administration, improved patient compliance and comfort. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation from which the drug gets released in a sustained and controlled manner. Various biodegradable polymers that are used for the formation of in situ gels include pectin, guar gum, carbopol, Xyloglucan, gellan gum, alginic acid, Xanthum gum, Chitosan, HPMC, Poloxamer etc. Mainly in situ gel administered by oral ocular, rectal, vaginal, injectable and intaperitoneal routes. This review presents a brief introduction to in situ gels, various approaches for in situ gelling system, different types of polymers used and evaluation of in situ gelling system.

Keywords: In situ gel, biodegradable polymer, pH sensitive, temperature sensitive.