ANALYSIS OF TOXICITY OF LEAD, ALCOHOL AND VITAMIN E ON CATALASE ACTIVITYOF LIVER TISSUE IN RATS
*Harishekar M.B.
Department of Biochemistry, Kempegowda Institute of Medical Sciences, Banashankari Bangalore, India.
ABSTRACT
The effect of lead, alcohol and vitamin E was analyzed in rats liver
tissue treated for four and eight weeks of duration. At four weeks of
treatment, in lead treated rats the catalase activity was 19.75
μg/min/gm of liver tissue, in alcohol treated rats, it was recorded
15.95, in lead and alcohol treated rats, the catalase activity was 11.05
compared to control it was 19.75 μg/min/gm of liver tissue. In
vitamin E treated rats the catalase activity was 21.95, in lead with
Vitamin E treated rats it was 17.08, in Alcohol with vitamin E it was
15.85 and in combination of lead, Alcohol and Vitamin E treatment
the catalase activity was 13.43 μg/min/gm of liver tissue. In eight
weeks of treatment, the catalase activity was 21.07 in lead treated rats,
13.53 in Alcohol and 8.78 in lead with alcohol treated rats. Compared
to control, it was 21.07 μg/min/gm of liver tissue.In Vitamin E treated
rats, the catalase activity was 21.73, in lead with vitamin E, it was
17.18, in Alcohol with Vitamin E the catalase activity was 14.58 and
in combination of lead, alcohol and vitamin E it was recorded 12.02 μg/min/gm of liver
tissue.
Keywords: Catalase, Lead, Alcohol, Vitamin E, Liver tissue, Rats.
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