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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ANALYSIS OF INTERACTION OF HUMAN HEMOGLOBIN WITH QUERCETIN: FLUORESCENCE SPECTROSCOPIC AND MOLECULAR MODELING APPROACH

S. Bakkialakshmi* and Jayoti Roy

ABSTRACT

Quercetin (3,3',4',5,7-pentahydroxyflavone), a plant derived flavonoid posseses a wide range of therapeutic properties such as anti-oxidant, anti-cancer, anti-tumor, etc. The purpose of this communication is to examine the interaction of Quercetin with natural drug carrier, Human hemoglobin (Hb) utilizing absorption spectroscopy, steady-state fluorescence and synchronous fluorescence spectroscopy and molecular modeling. The results indicated that quercetin caused strong fluorescence quenching of Hb by static quenching mechanism. Stern-Volmer study indicates that static along with quenching mechanisms are accountable for the quenching of protein fluorescence by quercetin. Molecular docking studies support the interactions between Hb and quercetin as observed from spectroscopic studies.

Keywords: Human hemoglobin, quercetin, steady-state fluorescence, synchronous fluorescence, molecular docking study.

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