Abstract

FORMULATION AND EVALUATION OF A NOVEL NON STEROIDAL ANTI INFLAMMATORY ZALTOPROFEN GEL

Sonali Mahaparale* and Atikaya Gaikwad

ABSTRACT

Zaltoprofen drug is a novel NSAIDsit has powerful inhibitory effects on acute& chronic inflammation with less adverse reaction on the gastrointestinal tract. The Zaltoprofen gel product was prepared in varied concentrations (5% and 10%) and evaluated using physiological measurements. The NSAIDs gel was formulated by using polymer such as Carbopol 934. The prepared gel formulations was evaluated by using the different parameter such as physical appearance, pH, viscosity, spread ability, Drug content and also skin irritation to observe toxicity or side effects of the formulation. The prepared gels formulations were evaluated for anti-inflammatory activity on albino mice. From the study it was concluded that gel formulation containing the concentration 10% have better spredability and stability than concentration 5%. The gel formulation containing the zaltofropen drug have clear appearance, Ph-7, good wash ability and good spredability and No skin irritation.Finally it was concluded that the Zaltoprfen gel formulation was the best product as compare to marketed product.

Keywords: Anti-inflammatory, zaltoprofen, Carbopol 934.