Abstract

FORMULATION AND EVALUATION OF POLYMER COMPOSITE FILMS OF ERYTHROMYCIN WITH ALOE VERA

S. Sujatha*, K. Kishore Kumar, Rahul Rao, Sk. Ershadul Haque and J. Siva Jyothi

ABSTRACT

Last few decades research has been focused in the development of highly therapeutic techniques and cost effective treatment procedure for wound healing. In this current study, we have mainly focused on the advanced and effective treatment procedure for bacterial infected wounds. Chitosan and sodium alginate based biodegradable composite films have been developed by solvent casting method. The efficacy of the biodegradable films enhanced by incorporation of antimicrobial agent Erythromycin and aloe vera as a wound healing accelerator in the film. The developed biodegradable films composite are analyzed by Fourier transform infra red spectroscopy (FTIR) to confirm the ionic complexation between the polymers. Blank composite films are evaluated based on thickness, folding endurance, swelling index and water vapor penetration. In vitro dissolution study carried out for drug loaded composite films followed by in vivo study (Both for blank and drug loaded composite films).

Keywords: Composite film, Chitosan, Aloe vera, Erythromycin, Wound healing