Abstract

FORMULATION, EVALAUTION AND OPTIMIZATION OF AN ORAL FLOATING ANTIBIOTIC TABLET

Surinder Kaur*, Falguni Das and Tusharkumar h. sorathiya

ABSTRACT

The present study in the development of Hydrodynamically Balanced Systems (HBS) of Cefpodoxime proxetil, third generation antibiotic drug which are designed to increase the gastric residence time, thus prolonging the drug release. Cefpodoxime proxetil is active against most Gram positive and Gram negative organisms it is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. Hydroxy propyl methyl cellulose (HPMC K 4 M) and Carbopol-934 of different ratio were used to prepare HBS by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, invitro floating studies, invitro drug release and short term stability studies. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBs formulations showed good invitro floating properties with an optimum concentration of gas generating agents sodium bicarbonate and citric acid. The rate of drug release decreased with increased hardness of tablets. Optimum concentration of HPMC K4M (70%) and Carbopol-934 (30%) along with excipients was found to be beneficial in improving the drug release rate and floating properties. Among the five formulations, F 4 was selected as the best formulation as its lag time 18 seconds, swelling index 100% and %CDR was 56.86% at 7 th hour with buoyancy time > 12 hours was found.

Keywords: Cefpodoxime proxetil, Hydrodynamically Balanced Systems, Hydroxy Propyl Methyl Cellulose (HPMC K4 M), Carbopol-934, Invitro floating.