Abstract

A BRIEF REVIEW OF MICROPARTICLE DRUG DELIVERY SYSTEM

N. Jyothi*, Harekrishna Roy, N. Lakshmi Prasanhti and V. Sri Vajrapriya

ABSTRACT

Microparticles are recently being focused as novel drug delivery systems, especially for suitability for their wider field of application. The particles range from one micron to few mm. Micro particles are mainly used for the protection of drug from degradation and for local and control drug delivery systems. These microparticles are 2 types’ microreservior and micromatrix. The main drawback of this system is dose-dumping of drug occurs in device. Different types of methods are used for the preparation of microparticles like solvent extraction, double emulsion, water-in-oil systems, phase separation and chemically and therapeutic methods like hot melt techniques. While preparing the device the selection of polymer and suitability of therapeutic agents are also to be considered. Microparticulate drug delivery dosage form are having a wide range of applications such as a drug carries in vaccine delivery, oral drug delivery, chemotherapy, drug targeting to organs, vaccines, ocular drug delivery, enhancement of bioavailability and Transdermal drug delivery systems.

Keywords: Microparticles, Microspheres, Solvent extraction, Phase separation.