Abstract

ARTEETHER- LOADED SOLID LIPID NANOPARTICULATE DISPERSION: DESIGN AND CHARACTERIZATION

Raksha L.Mhetre*, Vishal B. Hol, Amrita N. Bajaj, Ram B. Jadhav

ABSTRACT

Solid lipid nanoparticles (SLNs) are novel colloidal particles for oral delivery with enhanced solubility and absorption rate. They overcome the disadvantages of other colloidal carriers such as emulsion, liposome, and polymeric nanoparticles. β-arteether is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria. The aim of the study was to develop controlled release SLNs by incorporating this drug in to lipid nanocarriers where by nanosize of particles and lipid used for formulation would help to improve solubility of drug as well as control drug release over prolonged period. SLNs were prepared by High shear homogenization (HSH) technique using stearic acid as solid lipid core, Tween 80 and Poloxamer 188 as stabilizers. Formulations were optimized by 32 factorial design approaches. Particle size and size distribution were determined by Malvern Mastersizer and were found to be 400 nm with polydispersity index 0.28.Transmission Electron Microscopy showed that SLNs were uniform, and spherical in shape. In vitro release studies showed that the SLNs dispersions were able to control the drug release and it followed diffusion controlled release mechanism. Palatability of nanodispersion was improved using sweetener and flavors. HSH was found to be effective method to prepare high quality SLNs for once day oral administration of β-arteether.

Keywords: Solid Lipid Nanoparticles, ?-arteether, High shear homogenization (HSH).