Abstract

TRASDERMAL DRUG DELIVERY SYSTEM: AN OVERVIEW

Swapnil Lembhe* and Asish Dev

ABSTRACT

The drug absorption can be takes place from the skin which is then enters into systematic circulation over a period of time. Transdermal drug delivery system (TDDS) specialists are continuously working on the new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with oral route. Delivery of drugs through the skin has been always a challenging area for research because skin stratum corneum exibit some barrier properties. The transdermal drug delivery system offers significant clinical benefits over other dosage forms, because transdermal drug delivery offers controlled as well as predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration. It’s a widely used form of drug delivery because of some advantages e.g. convenient and pain-free self-administration for patients, avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs. The present article reviews the selection of drug candidates and polymers, advantages, disadvantages of formulation, design and the methods of evaluation, enhancement techniques based on drug/vehicle optimization such as drug selection, prodrugs and ion pairs, supersaturated drug solutions, complexations, liposomes, vescicles and particles. This review also focuses on the recent innovations in TDDS, which can be used for the research and development of pharmaceutical dosage form for transdermal drug delivery.

Keywords: TDDS, first pass metabolism, site specific.