Abstract

GASTRO-RETENTIVE DRUG DELIVERY SYSTEM: A REVIEW ON ITS RECENT ADVANCEMENT

Swapnil Lembhe*, Avanti Mhatre* and Asish Dev

ABSTRACT

GRDDs are an approach to prolong gastric residence time of the drugs. GRDFs improves the bioavailability of drugs that have narrow therapeutic window. GRDFs allows prolonged and continuous drug release to the upper part of Gastro intestinal tract (GIT) by this way they prolong dosing interval and increase compliance of the patient. Oral route is most widely used route for the drug administration but it has certain limitations for those drugs which absorb from specific region of gastrointestinal tract. To overcome these limitations, various approaches have been proposed to increase gastric retention of drug in the upper part of the GIT, includes floating drug dosage systems (FDDS), swelling or expanding systems, bio/mucoadhesive systems, raft forming system, magnetic systems, modified-shape systems, super porous hydrogel system, high density system and other delayed gastric emptying devices. The aim of writing this review on gastroretentive drug delivery system was to present the recent literature with special focus on various formulation techniques and and their advantages and disadvantages to achieve gastric retention. In addition, important factors controlling gastro retention, advantages, analysis techniques, recent trends and finally, future potentials are also discussed.

Keywords: Floating Drug delivery system and Bioadhesion, Gastric retention time, Gastric emptying time, Swelling System.