Abstract

THE SIGNIFICANCE OF DETERMINATION OF PEPSINOGEN A, PEPSINOGEN C, GASTRIN, CD44, AND INTERFERON GAMMA IN INDIVIDUALS WITH GASTRITIS

Abdulghani M. Alsamarai*, Fatima Thegel Moutar, Farooq Ibrahem Mohammad

ABSTRACT

Background: Helicobacter pylori infection is with worldwide distribution with public health impact and high morbidity and mortality especially in developing countries. Aim: investigated the significance of pepsinogen A, pepsinogen C, gastrin, CD 44, and interferon gamma as screening test for gastritis with Helicobacter pylori positive compared to those who are Helicobacter pylori negative cases. Materials and Methods: Serum collected from 136 subjects; of the 72 were H. pylori positive and 64 were H. pylori negative as control group. H. pylori antibody, pepsinogen A, pepsinogen C, CD44, gastrin and interferon gamma were determined by ELISA method. Results: Serum pepsinogen A was significantly lower in H. pylori positive gastritis as compared to H. pylori negative gastritis. In contrast, pepsinogen C, gastrin, CD44 and interferon gamma serum levels were significantly higher in H. pylori positive gastritis as compared to H. pylori negative gastritis. Both OR and area under ROC curve indicated a significant association between pepsinogen A, pepsinogen C, gastrin, CD 44 and interferon gamma serum levels and H pylori positivity in patients with gastritis. The predictive value was higher for pepsinogen C and lower for gastrin in both OR and AUC calculation. Conclusion: serum pepsinogen A and C, gastrin, CD44 and IFN-γ are a predictor of H. pylori positive gastritis. Pepsinogen C serum levels are the best predictor, while gastrin is the lower predictor. However, a large scale study is warranted with the use of H. pylori negative without gastritis as control group.

Keywords: Gastritis, H. pylori, Pepsinogen, CD44, Gastrin, Interferon.