Abstract

PHARMACOKINETICS OF TILMICOSIN IN HEALTHY AND EXPERIMENTALLY PASTREULLA MULTOCIDA INFECTED LACTATING GOATS.

Ashraf Abd El-Hakim Ahmed El-Komy, Mossad Gamal El-Din Ahmed El Sayed, Elham Ahmed Mobarez, Hanan Ahmed Azoz and Amir Ezzat Afify*

ABSTRACT

Tilmicosin was administered subcutaneously at a dose rate of 10 mg/kg. b.wt to determine its concentrations in blood as well as its kinetic behavior in healthy and experimentally Pstaerulla multocida infected lactating goats. Tilmicosin was detectable in plasma for 72 hours. The mean peak plasma concentrations (Cmax) in healthy and experimentally Pstaerulla multocida infected lactating goats were 1.07 ± 0.052 μg/ml , and 0.92 ± 0.016 μg/ml achieved at a maximum times (Tmax) of 1.91 ± 0.19 hour and 1.65± 0.18 hour, respectively. Tilmicosin was slowly eliminated from plasma indicated by its half- life (T0.5el) of 28.02 ± 4.025 hours and 26.55 ± 2.39 hours, respectively.

Keywords: Pharmacokinetics, Tilmicosin, pastreulla multocida, HPLC, Lactating goats.