Abstract

SIGNIFICANT CHANGE IN SERUM TOTAL PROTEIN AND ALBUMIN IN HEALTHY FRIST TIME PLATELETPHERESIS DONORS.

V. B. Mane*, P. E. Jagtap, N. S. Nagane, G. J. Belwalkar, S. P. Dhonde, S. M. More and V. Bhandare

ABSTRACT

Background:- The apheresis is an efficient method to collect one or more specific blood component. The advantage of apheresis includes the collection of standardized high quality product, and more than one product from single donor.[1] We planned this study to observe the effect of citrate infusion in plateletpheresis donors and to determine whether the biochemical alteration had any clinical consequences and also focus the altered mineral metabolism in first time plateletpheresis donation. Study design and methods:- The study was conducted on 62 healthy first time voluntary plateletpheresis donors with age group between 21 to 50 years, at Apheresis unit in blood bank Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli. Plateletpheresis procedures were performed by using cell separator machine Fenwal Amicus Cell Separator (Baxter Healthcare Corporation Deerfield IL USA). Biochemical values of serum total protein and albumin were measured in all 62 donors, pre and post apheresis procedure. Result:- We observed that the serum total protein and albumin decreased significantly in the plateletpheresis donors ( p < 0.001) after each procedure in all donors. Conclusion:- There is significantly decreased in serum total protein and albumin ( P< 0.001). In the context we suggest the donor should be screened for biochemical investigation serum total protein and albumin along with the serological and hematological investigation at first time plateletpheresis donation. These biochemical investigations will be definitely useful in providing the transfusion consultant in the management of plateletpheresis complications.

Keywords: ACD infusion; Biochemical levels; Citrate side effect; Hypoproteinmia; Hypoalbuminemia; Plateletpheresis.