SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF SOME PYRIMIDINE DERIVATIVES CONTAINING QUINOLINE RING.
Dr. Vivek S. Patel*, Dr. Divyanshu D. Patel, Dr. Mayank S. Patel, Dr. P. S. Patel, Prof. K. C. Patel
ABSTRACT
A series of 4-(2-chloro-5,7-diflouro quinolin-3-yl)-6-(substituted phenyl)pyrimidine-2-thiol have been synthesized by reacting 2-chloro 5,7-diflouro 3-carbaldehyde with various substituted acetophenone and then condensed with thiourea. All the synthesized compounds were characterized by elemental analysis, IR spectra and 1H NMR spectra. They were evaluated for their antimicrobial activity.
Keywords: Quinoline chalcone, quinolinyl pyrimidine, antimicrobial activity.
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