Abstract

INSILICO STUDIES OF POLYPEPTIDE-p AND AMYLIN: SIGNIFICANCE AND THEIR SUBSEQUENTLY ASSOCIATION WITH DIABETES MELLITUS

Rafat Ali, Abdul Rahaman*, Mahafooj Alee, Taj Mohammad, Ankita Kumari, Muneesh Pal, Rajan Kumar Tiwari and Vivek Dubey

ABSTRACT

Diabetes is a disorder mainly related to the endocrine system, which is characterized by the failure of kidney, increasing secretion of urine because of the osmotic effect of glucose. It’s a major problem of our society. The amylin and polypeptide-p both play a crucial role in diabetes these are having antidiabetic properties. Polypeptide-p, vicine and charantin are three researched compound which are present in the momordica charantia. These are responsible for antidiabetic activity. They increase uptake of glucose and improve glucose tolerance. The amylin is a hormone which is secreted with insulin so that it is deficient in diabetic patients. Amylin inhibits glucagon and act as satiety agent; therefore it could be possible to improve in some diabetic patients. All of its action tends to reduce the level of glucose in the blood.

Keywords: Diabetes, Amylin, Polypeptide-p, Glucagon, Insulin and Bioinformatics.