Abstract

EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF SOLANUM TORVUM IN ISOPROTERENOL INDUCED RATS

Victor Arokia Doss D., Suresh S. and *Sowndarya R.

ABSTRACT

Objective: To evaluate the cardioprotective effect hydroethanolic extract of solanum torvum against isoproterenol induced myocardial infarction in Wistar rats. Methods: In this study, cardioprotective effect hydroethanolic extract of solanum torvum (at the dosage of 200 mg/kg body weight for 30 days) against isoproterenol induced rats were studied and also compared with standard drug Propranolol. MI was induced with a single dose of ISO (85 mg/kg) on the 29th and 30th day. At the end of 30 days (i.e., on the day 31st), serum and heart tissues were collected and lipid profiles such as cholesterol, triglycerides, LDL and HDL were estimated in serum. Histopathology of heart samples was also performed. Results: Administration of ISO in control rats showed a significant increase serum Total Cholesterol (TC), Triglycerides (TG), low density lipoprotein (LDL) and decrease in High density lipoprotein (HDL). Rats treated with hydroethanolic extract of solanum torvum (200 mg/kg body weight) showed decreased TC, TG, LDL and increases HDL levels. The histopathological studies also showed that Plant extract significantly minimized the damage induced by isoproterenol. Conclusion: Thus, solanum torvum provide cardioprotection against isoproterenol induced myocardial infarction in rats.

Keywords: Solanum torvum, Isoproterenol, Myocardial infarction, Propranolol.