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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

AN IN VITRO ANTICANCER ACTIVITY OF AQUEOUS EXTRACT OF TRITICUM AESTIVUM ON HEP2 HUMAN EPITHELIOMA OF LARYNX CELL LINE.

Dr. Janki B. Patel*

ABSTRACT

The study was aimed to evaluation of anticancer activity of the leaves of Triticum aestivum on Hep‐2 cell line from human epithelioma of larynx. The aqueous extract of leaves of Triticum aestivum was tested for its inhibitory effect on Hep‐2 cell line in comparison with the Vero (normal kidney cells) cell line. The cytotoxic activity was investigated in-vitro using 3‐(4, 5‐dimethyl thiazol‐2yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay. The potency of each plant extract concentration was calculated in terms of percent cell inhibition of HEp‐2 cells as compared to the Vero (normal kidney cells) cell line. The extract showed dose dependent antitumor activity. The MTT assay showed an anti proliferative activity (IC50) for the HEp- 2 cell line at 335.3 μg/ml of crude extract.

Keywords: Triticum aestivum, HEp?2 cells, Vero cell line, MTT assay, Cytotoxicity.

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