Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF SALBUTAMOL

Mounika Pokala*, Krishnakanth Pawarkar, Ramya Krishna Tammira, Priyanka Mamidi, Umadevi Racha and Lahari Samudrala

ABSTRACT

The present study was aimed at preparing a transdermal patch of an antiasthamatic agent Salbutamol using different concentrations of polymers like ethyl cellulose, hydroxy propyl methyl cellulose and PEG 6000. The drug Salbutamol is a short-acting, selective β2 adrenergic receptor agonist used in the treatment of asthma. Transdermal drug delivery is a technique that is used to deliver a drug into the systemic circulation across the skin. It provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. Transdermal drugs are self contained, discrete dosage form. It is an alternative to oral, intravascular, subcutaneous and transmucosal route. Much attention has been given in recent years with regard to transdermal delivery devices. Broadly this system can be considered as single layer and multilayer. Ficks first law of diffusion is the principle of drug kinetics. Drug related factors and a physicochemical property of membranes affects drug penetration. The prepared polymeric films were evaluated for their physical properties like percentage flatness, thickness uniformity, drug content and diffusion studies.

Keywords: Transdermal, intravascular, subcutaneous, transmucosal, bronchodilator, salbutamol.