Abstract

OVER VIEW- ION EXCHANGE RESINS IN CONTROLLED DRUG DELIVERY SYSTEM

Venkatesh DP*, Roopa karki, Divakar Goli, Sajal Kumar Jha

ABSTRACT

Controlled release drug delivery systems are gaining popularity. One of the attractive methods for modified drug delivery systems preferably controlled type is ion-exchange resins as carriers for such systems. Ionexchange resinates of drugs can help in reducing the dose. Reduced fluctuations in blood and tissue concentrations and maintenance of drug concentration below toxic level can be achieved. Ample work was done and patents were reported with the preparation and evaluation of resinates for a large variety of drugs. Ion exchange resins have specific properties like available capacity, acid base strength, particle size, porosity and swelling properties. The ion exchange resins are complexed with drug to form resinates by batch or column process. Microencapsulated resinates provides better control over the drug release because of the rate controlling membrane.

Keywords: Microencapsulation; Ion exchange resins; Drug-resinates; Controlled release.